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The job details are as follows:

Scientist (Associate) Cell Sourcing

What We Do

We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.

We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.

Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.

With over 100,000 patients on the organ transplant waitlist and only a fraction receiving the lifesaving organ they require, there is a great need for additional sources of transplantable organs. At Miromatrix, a leader in regenerative medicine and a subsidiary of United Therapeutics Corporation, we are working to address this unmet need by bioengineering human organs to help save and improve patients’ lives. Join our team as we continue to make history by developing life-saving therapies to help patients with liver and kidney disease.

How you’ll contribute

• Conduct research to develop and refine robust protocols for the isolation and expansion of primary liver and kidney cells. Protocol design will include development of control mechanisms geared toward implementation of GMP level large-scale manufacturing processes.

• Essential Job Duties & Responsibilities

• Coordinate with R&D and manufacturing teams to generate technical plans to develop and refine targeted primary cell isolation protocols from human liver and kidney tissue

• Draft protocols, experimental documentation strategies, summaries, and reports. Assist in preparation for regulatory submissions

• Work with a team on a flexible schedule, according to organ availability, to conduct primary cell isolation protocols

• Contribute to design and execution of experiments to develop methods for downstream purification and expansion of primary liver and kidney cells

• Work with manufacturing and engineering teams to design methods of control for the generation of reliable primary cell manufacturing processes

• Perform characterization of cells obtained from isolation and expansion protocols using standard techniques such as flow cytometry and IHC

• Assist in coordination and training activities for transfer of fully developed protocols to manufacturing and cell production teams

• Communicate using both oral presentations and written documents to broad level of audiences including R&D teams, quality, manufacturing, and upper management.

• Contribute to efforts to understand, explore, and incorporate new technologies to advance programs

• Keep up to date on relevant literature and serve as a technical expert in applicable scientific subject matter

• Mentor, advise, and train junior staff

• Assist with drafting and submission of manuscripts, grants, and abstracts with approval of senior management

For this role you will need

Minimum Requirements

• Doctor of Philosophy (PhD) in tissue engineering, biomedical engineering, biological sciences, or related field (preferred) with 1+ years relevant experience working with adherent mammalian cell culture, primary cell isolations, and cell characterization techniques or:

• Master’s Degree in tissue engineering, biomedical engineering, biological sciences, or related field with 5+ years of relevant experience working with adherent mammalian cell culture, primary cell isolations, and cell characterization techniques.

• 1+ years working in a regulated industry setting

• Experience with adherent mammalian cell culture

• Experience generating ideas and progressing experimental phase of R&D projects

• Enthusiasm for a collaborative work culture and desire to make a positive impact

• Excellent organizational, verbal, written, and interpersonal skills

• Ability to work in a fast-paced environment, including multi-tasking, flexibility, and adaptability

• Ability to work off hours when necessary according to organ availability

Preferred Qualifications

• Experience working in a quality controlled setting

• Experience with primary cell isolations

• Background knowledge of liver and/or kidney function and experience working with cells from these organs

• Experience working with human tissue

• Experience working in a clinical setting and performing studies for regulatory submission preparation

• Experience with cell purification techniques such as MACS sorting or size exclusion

• Experience with flow cytometry

• Experience with immunohistochemistry or immunofluorescence staining

• Background knowledge of perfusion control and fluid flow dynamics

At United Therapeutics you’ll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.

While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients.

United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities

We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success.

We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work.